SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells

Phenotypic conversion of tumor cells through epithelial-mesenchymal transition (EMT) requires massive gene expression changes. How these are brought about is not clear. Here we examined the impact of the EMT master regulator SNAIL1 on the FOXA family of transcription factors which are distinguished...

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Detalles Bibliográficos
Autores principales: Jägle, Sabine, Busch, Hauke, Freihen, Vivien, Beyes, Sven, Schrempp, Monika, Boerries, Melanie, Hecht, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714381/
https://www.ncbi.nlm.nih.gov/pubmed/29155818
http://dx.doi.org/10.1371/journal.pgen.1007109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714381/
https://www.ncbi.nlm.nih.gov/pubmed/29155818
http://dx.doi.org/10.1371/journal.pgen.1007109

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