Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination

Antigen receptor gene assembly is accomplished in developing lymphocytes by the V(D)J recombination reaction, which can be separated into two steps: DNA cleavage by the recombination-activating gene (RAG) nuclease and joining of DNA double strand breaks (DSBs) by components of the nonhomologous end...

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Detalles Bibliográficos
Autores principales: Lenden Hasse, Hélène, Lescale, Chloé, Bianchi, Joy J., Yu, Wei, Bedora-Faure, Marie, Deriano, Ludovic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714433/
https://www.ncbi.nlm.nih.gov/pubmed/28882611
http://dx.doi.org/10.1016/j.jim.2017.08.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714433/
https://www.ncbi.nlm.nih.gov/pubmed/28882611
http://dx.doi.org/10.1016/j.jim.2017.08.007

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