A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

Mutations in LRRK2 are a common cause of genetic Parkinson’s disease (PD). LRRK2 is a multi-domain Roco protein, harbouring kinase and GTPase activity. In analogy with a bacterial homologue, LRRK2 was proposed to act as a GTPase activated by dimerization (GAD), while recent reports suggest LRRK2 to...

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Detalles Bibliográficos
Autores principales: Deyaert, Egon, Wauters, Lina, Guaitoli, Giambattista, Konijnenberg, Albert, Leemans, Margaux, Terheyden, Susanne, Petrovic, Arsen, Gallardo, Rodrigo, Nederveen-Schippers, Laura M., Athanasopoulos, Panagiotis S., Pots, Henderikus, Van Haastert, Peter J. M., Sobott, Frank, Gloeckner, Christian Johannes, Efremov, Rouslan, Kortholt, Arjan, Versées, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714945/
https://www.ncbi.nlm.nih.gov/pubmed/29044096
http://dx.doi.org/10.1038/s41467-017-01103-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714945/
https://www.ncbi.nlm.nih.gov/pubmed/29044096
http://dx.doi.org/10.1038/s41467-017-01103-4

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