KIF1Bβ increases ROS to mediate apoptosis and reinforces its protein expression through O(2)(−) in a positive feedback mechanism in neuroblastoma

Relapse-prone, poor prognosis neuroblastoma is frequently characterized by deletion of chr1p36 where tumor suppressor gene KIF1Bβ resides. Interestingly, many 1p36-positive patients failed to express KIF1Bβ protein. Since altered cellular redox status has been reported to be involved in cell death a...

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Detalles Bibliográficos
Autores principales: Angelina, Clara, Tan, Irene Sze Ying, Choo, Zhang’e, Lee, Oswald Zhao Jian, Pervaiz, Shazib, Chen, Zhi Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715000/
https://www.ncbi.nlm.nih.gov/pubmed/29203804
http://dx.doi.org/10.1038/s41598-017-17192-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715000/
https://www.ncbi.nlm.nih.gov/pubmed/29203804
http://dx.doi.org/10.1038/s41598-017-17192-6

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