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KIF1Bβ increases ROS to mediate apoptosis and reinforces its protein expression through O(2)(−) in a positive feedback mechanism in neuroblastoma
Relapse-prone, poor prognosis neuroblastoma is frequently characterized by deletion of chr1p36 where tumor suppressor gene KIF1Bβ resides. Interestingly, many 1p36-positive patients failed to express KIF1Bβ protein. Since altered cellular redox status has been reported to be involved in cell death a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715000/ https://www.ncbi.nlm.nih.gov/pubmed/29203804 http://dx.doi.org/10.1038/s41598-017-17192-6 |