De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies

Aberrant RNA-binding proteins form the core of the neurodegeneration cascade in spectrums of disease, such as amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). Six ALS-related molecules, TDP-43, FUS, TAF15, EWSR1, heterogeneous nuclear (hn)RNPA1 and hnRNPA2 are RNA-binding proteins...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitsuhashi, Kana, Ito, Daisuke, Mashima, Kyoko, Oyama, Munenori, Takahashi, Shinichi, Suzuki, Norihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715010/
https://www.ncbi.nlm.nih.gov/pubmed/29203801
http://dx.doi.org/10.1038/s41598-017-17209-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715010/
https://www.ncbi.nlm.nih.gov/pubmed/29203801
http://dx.doi.org/10.1038/s41598-017-17209-0

Ejemplares similares