High expression of β-catenin contributes to the crizotinib resistant phenotype in the stem-like cell population in neuroblastoma

ALK has been identified as a novel therapeutic target in neuroblastoma (NB), but resistance to ALK inhibitors (such as crizotinib) is well recognized. We recently published that the crizotinib sensitivity in NB cells strongly correlates with the crizotinib—ALK binding, and β-catenin effectively hind...

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Detalles Bibliográficos
Autores principales: Alshareef, Abdulraheem, Gupta, Nidhi, Zhang, Hai-Feng, Wu, Chengsheng, Haque, Moinul, Lai, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715105/
https://www.ncbi.nlm.nih.gov/pubmed/29203817
http://dx.doi.org/10.1038/s41598-017-17319-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715105/
https://www.ncbi.nlm.nih.gov/pubmed/29203817
http://dx.doi.org/10.1038/s41598-017-17319-9

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