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Preclinical and clinical advances in transposon-based gene therapy

Transposons derived from Sleeping Beauty (SB), piggyBac (PB), or Tol2 typically require cotransfection of transposon DNA with a transposase either as an expression plasmid or mRNA. Consequently, this results in genomic integration of the potentially therapeutic gene into chromosomes of the desired t...

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Detalles Bibliográficos
Autores principales:	Tipanee, Jaitip, Chai, Yoke Chin, VandenDriessche, Thierry, Chuah, Marinee K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2017
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715130/ https://www.ncbi.nlm.nih.gov/pubmed/29089466 http://dx.doi.org/10.1042/BSR20160614

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