Targeted kinase inhibition relieves slowness and tremor in a Drosophila model of LRRK2 Parkinson’s disease

In a number of Drosophila models of genetic Parkinson’s disease (PD) flies climb more slowly than wild-type controls. However, this assay does not distinguish effects of PD-related genes on gravity sensation, “arousal”, central pattern generation of leg movements, or muscle. To address this problem,...

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Detalles Bibliográficos
Autores principales: Cording, Amy C., Shiaelis, Nicolas, Petridi, Stavroula, Middleton, C. Adam, Wilson, Laurence G., Elliott, Christopher J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715132/
https://www.ncbi.nlm.nih.gov/pubmed/29214211
http://dx.doi.org/10.1038/s41531-017-0036-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715132/
https://www.ncbi.nlm.nih.gov/pubmed/29214211
http://dx.doi.org/10.1038/s41531-017-0036-y

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