Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1–SUFU Interaction in PDA Cells

Dysregulation of Hedgehog (Hh) signaling pathway is one of the hallmarks of pancreatic ductal adenocarcinoma (PDA). Lithium, a clinical mood stabilizer for the treatment of mental disorders, is known to suppress tumorigenic potential of PDA cells by targeting the Hh/Gli signaling pathway. In this st...

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Detalles Bibliográficos
Autores principales: Wang, Xinshuo, Fang, Zijian, Wang, Anlin, Luo, Cheng, Cheng, Xiaodong, Lu, Meiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715333/
https://www.ncbi.nlm.nih.gov/pubmed/29249966
http://dx.doi.org/10.3389/fphar.2017.00820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715333/
https://www.ncbi.nlm.nih.gov/pubmed/29249966
http://dx.doi.org/10.3389/fphar.2017.00820

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