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Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization

γ-secretase is an intramembrane protease complex consisting of nicastrin, presenilin-1/2, APH-1a/b, and Pen-2. Hydrolysis of the 99-residue transmembrane fragment of amyloid precursor protein (APP-C99) by γ-secretase produces β-amyloid (Aβ) peptides. Pathogenic mutations in PSEN1 and PSEN2, which en...

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Detalles Bibliográficos
Autores principales: Zhou, Rui, Yang, Guanghui, Shi, Yigong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715776/
https://www.ncbi.nlm.nih.gov/pubmed/29078389
http://dx.doi.org/10.1073/pnas.1713605114