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Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization
γ-secretase is an intramembrane protease complex consisting of nicastrin, presenilin-1/2, APH-1a/b, and Pen-2. Hydrolysis of the 99-residue transmembrane fragment of amyloid precursor protein (APP-C99) by γ-secretase produces β-amyloid (Aβ) peptides. Pathogenic mutations in PSEN1 and PSEN2, which en...
Autores principales: | Zhou, Rui, Yang, Guanghui, Shi, Yigong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715776/ https://www.ncbi.nlm.nih.gov/pubmed/29078389 http://dx.doi.org/10.1073/pnas.1713605114 |
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