Celastrol improves self-renewal and differentiation of human tendon-derived stem cells by suppressing Smad7 through hypoxia

BACKGROUND: We aimed to evaluate the potential enhancing effect of celastrol on the stemness of human tendon-derived stem cells (hTSCs) in vitro and the underlying molecular mechanisms. METHODS: The capability of hTSC self-renewal was assessed by cell proliferation and colony formation as determined...

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Detalles Bibliográficos
Autores principales: Wu, Tianyi, Liu, Shenghe, Wen, Gen, Xu, Jia, Yu, Yaling, Chai, Yimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715986/
https://www.ncbi.nlm.nih.gov/pubmed/29202812
http://dx.doi.org/10.1186/s13287-017-0724-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715986/
https://www.ncbi.nlm.nih.gov/pubmed/29202812
http://dx.doi.org/10.1186/s13287-017-0724-x

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