USP1–UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses

Optimal activation of TANK-binding kinase 1 (TBK1) is crucial for initiation of innate antiviral immunity and maintenance of immune homeostasis. Although several E3 ubiquitin ligases have been reported to regulate TBK1 activation by mediating its polyubiquitination, the functions of deubiquitinase o...

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Detalles Bibliográficos
Autores principales: Yu, Zhongxia, Song, Hui, Jia, Mutian, Zhang, Jintao, Wang, Wenwen, Li, Qi, Zhang, Lining, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716033/
https://www.ncbi.nlm.nih.gov/pubmed/29138248
http://dx.doi.org/10.1084/jem.20170180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716033/
https://www.ncbi.nlm.nih.gov/pubmed/29138248
http://dx.doi.org/10.1084/jem.20170180

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