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The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3
Lysine methylation is an important posttranslational modification, implicated in various biological pathological conditions. The transcription factor interferon regulatory factor 3 (IRF3) is essential for antiviral innate immunity, yet the mechanism for methylation control of IRF3 activation remains...
Autores principales: | Wang, Chunmei, Wang, Qinlan, Xu, Xiaoqing, Xie, Bin, Zhao, Yong, Li, Nan, Cao, Xuetao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716042/ https://www.ncbi.nlm.nih.gov/pubmed/29101251 http://dx.doi.org/10.1084/jem.20170856 |
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