A role for astroglia in prion diseases

In this issue of JEM, Krejciova et al. (https://doi.org/10.1084/jem.20161547) report that astrocytes derived from human iPSCs can replicate human CJD prions. These observations provide a new, potentially very valuable model for studying human prions in cellula and for identifying antiprion compounds...

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Detalles Bibliográficos
Autores principales: Aguzzi, Adriano, Liu, Yingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716049/
https://www.ncbi.nlm.nih.gov/pubmed/29162644
http://dx.doi.org/10.1084/jem.20172045
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author Aguzzi, Adriano
Liu, Yingjun
author_facet Aguzzi, Adriano
Liu, Yingjun
author_sort Aguzzi, Adriano
collection PubMed
description In this issue of JEM, Krejciova et al. (https://doi.org/10.1084/jem.20161547) report that astrocytes derived from human iPSCs can replicate human CJD prions. These observations provide a new, potentially very valuable model for studying human prions in cellula and for identifying antiprion compounds that might serve as clinical candidates. Furthermore, they add to the evidence that astrocytes may not be just innocent bystanders in prion diseases.
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spelling pubmed-57160492018-06-04 A role for astroglia in prion diseases Aguzzi, Adriano Liu, Yingjun J Exp Med News In this issue of JEM, Krejciova et al. (https://doi.org/10.1084/jem.20161547) report that astrocytes derived from human iPSCs can replicate human CJD prions. These observations provide a new, potentially very valuable model for studying human prions in cellula and for identifying antiprion compounds that might serve as clinical candidates. Furthermore, they add to the evidence that astrocytes may not be just innocent bystanders in prion diseases. The Rockefeller University Press 2017-12-04 /pmc/articles/PMC5716049/ /pubmed/29162644 http://dx.doi.org/10.1084/jem.20172045 Text en © 2017 Aguzzi and Liu http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Aguzzi, Adriano
Liu, Yingjun
A role for astroglia in prion diseases
title A role for astroglia in prion diseases
title_full A role for astroglia in prion diseases
title_fullStr A role for astroglia in prion diseases
title_full_unstemmed A role for astroglia in prion diseases
title_short A role for astroglia in prion diseases
title_sort role for astroglia in prion diseases
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716049/
https://www.ncbi.nlm.nih.gov/pubmed/29162644
http://dx.doi.org/10.1084/jem.20172045
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