Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells

DNA ‘sliding’ by human repair enzymes is considered to be important for DNA damage detection. Here, we transfected uracil-containing DNA duplexes into human cells and measured the probability that nuclear human uracil DNA glycosylase (hUNG2) excised two uracil lesions spaced 10–80 bp apart in a sing...

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Detalles Bibliográficos
Autores principales: Esadze, Alexandre, Rodriguez, Gaddiel, Weiser, Brian P., Cole, Philip A., Stivers, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716149/
https://www.ncbi.nlm.nih.gov/pubmed/29036472
http://dx.doi.org/10.1093/nar/gkx848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716149/
https://www.ncbi.nlm.nih.gov/pubmed/29036472
http://dx.doi.org/10.1093/nar/gkx848

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