hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cells

Ewing sarcomas (ES) are biologically aggressive tumors of bone and soft tissues for which no cure is currently available. Most ES patients do not respond to chemotherapeutic treatments or acquire resistance. Since the PI3K/AKT/mTOR axis is often deregulated in ES, its inhibition offers therapeutic p...

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Detalles Bibliográficos
Autores principales: Passacantilli, Ilaria, Frisone, Paola, De Paola, Elisa, Fidaleo, Marco, Paronetto, Maria Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716164/
https://www.ncbi.nlm.nih.gov/pubmed/29036465
http://dx.doi.org/10.1093/nar/gkx831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716164/
https://www.ncbi.nlm.nih.gov/pubmed/29036465
http://dx.doi.org/10.1093/nar/gkx831

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