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Genome-wide prediction of minor-groove electrostatic potential enables biophysical modeling of protein–DNA binding
Protein–DNA binding is a fundamental component of gene regulatory processes, but it is still not completely understood how proteins recognize their target sites in the genome. Besides hydrogen bonding in the major groove (base readout), proteins recognize minor-groove geometry using positively charg...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716191/ https://www.ncbi.nlm.nih.gov/pubmed/29040720 http://dx.doi.org/10.1093/nar/gkx915 |