Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST

Human CST (CTC1–STN1–TEN1) is a ssDNA-binding complex that helps resolve replication problems both at telomeres and genome-wide. CST resembles Replication Protein A (RPA) in that the two complexes harbor comparable arrays of OB-folds and have structurally similar small subunits. However, the overall...

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Detalles Bibliográficos
Autores principales: Bhattacharjee, Anukana, Wang, Yongyao, Diao, Jiajie, Price, Carolyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716219/
https://www.ncbi.nlm.nih.gov/pubmed/29040642
http://dx.doi.org/10.1093/nar/gkx878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716219/
https://www.ncbi.nlm.nih.gov/pubmed/29040642
http://dx.doi.org/10.1093/nar/gkx878

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