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The α6β4 integrin promotes resistance to ferroptosis

Increases in lipid peroxidation can cause ferroptosis, a form of cell death triggered by inhibition of glutathione peroxidase 4 (GPX4), which catalyzes the reduction of lipid peroxides and is a target of ferroptosis inducers, such as erastin. The α6β4 integrin protects adherent epithelial and carcin...

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Detalles Bibliográficos
Autores principales: Brown, Caitlin W., Amante, John J., Goel, Hira Lal, Mercurio, Arthur M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716272/
https://www.ncbi.nlm.nih.gov/pubmed/28972104
http://dx.doi.org/10.1083/jcb.201701136