RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability

Sgs1, the orthologue of human Bloom’s syndrome helicase BLM, is a yeast DNA helicase functioning in DNA replication and repair. We show that SGS1 loss increases R-loop accumulation and sensitizes cells to transcription–replication collisions. Yeast lacking SGS1 accumulate R-loops and γ-H2A at sites...

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Detalles Bibliográficos
Autores principales: Chang, Emily Yun-Chia, Novoa, Carolina A., Aristizabal, Maria J., Coulombe, Yan, Segovia, Romulo, Chaturvedi, Richa, Shen, Yaoqing, Keong, Christelle, Tam, Annie S., Jones, Steven J.M., Masson, Jean-Yves, Kobor, Michael S., Stirling, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716281/
https://www.ncbi.nlm.nih.gov/pubmed/29042409
http://dx.doi.org/10.1083/jcb.201703168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716281/
https://www.ncbi.nlm.nih.gov/pubmed/29042409
http://dx.doi.org/10.1083/jcb.201703168

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