Cargando…

Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low- to middle-income countries

BACKGROUND: Thymidine analogs, namely AZT (Zidovudine or Retrovir™) and d4T (Stavudine or Zerit™) are antiretroviral drugs still employed in over 75% of first line combination antiretroviral therapy (cART) in Kampala, Uganda despite aversion to prescribing these drugs for cART in high income countri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gibson, Richard M., Nickel, Gabrielle, Crawford, Michael, Kyeyune, Fred, Venner, Colin, Nankya, Immaculate, Nabulime, Eva, Ndashimye, Emmanuel, Poon, Art F. Y., Salata, Robert A., Kityo, Cissy, Mugyenyi, Peter, Quiñones-Mateu, Miguel E., Arts, Eric J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716384/ https://www.ncbi.nlm.nih.gov/pubmed/29202874 http://dx.doi.org/10.1186/s40249-017-0377-0

Ejemplares similares

First-line HIV treatment failures in non-B subtypes and recombinants: a cross-sectional analysis of multiple populations in Uganda
por: Poon, Art F. Y., et al.
Publicado: (2019)

Comparison of HIV drug resistance profiles across HIV-1 subtypes A and D for patients receiving a tenofovir-based and zidovudine-based first line regimens in Uganda
por: Ayitewala, Alisen, et al.
Publicado: (2020)

Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection
por: Klein, Katja, et al.
Publicado: (2018)

Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage
por: Nankya, Immaculate L, et al.
Publicado: (2015)

Infecting HIV-1 Subtype Predicts Disease Progression in Women of Sub-Saharan Africa
por: Venner, Colin M., et al.
Publicado: (2016)

HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa
por: Kityo, Cissy, et al.
Publicado: (2017)

Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda
por: Joussef-Piña, Samira, et al.
Publicado: (2022)

The urgent need for more potent antiretroviral therapy in low-income countries to achieve UNAIDS 90-90-90 and complete eradication of AIDS by 2030
por: Ndashimye, Emmanuel, et al.
Publicado: (2019)

Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial
por: Paton, Nicholas I, et al.
Publicado: (2017)

Zidovudine.
por: Sperling, R
Publicado: (1998)

HIV Drug Resistance Among Children Initiating First-Line Antiretroviral Treatment in Uganda
por: Kityo, Cissy, et al.
Publicado: (2016)

Towards 90-90-90 Target: Factors Influencing Availability, Access, and Utilization of HIV Services—A Qualitative Study in 19 Ugandan Districts
por: Bajunirwe, Francis, et al.
Publicado: (2018)

Rapid accumulation of HIV-1 thymidine analogue mutations and phenotypic impact following prolonged viral failure on zidovudine-based first-line ART in sub-Saharan Africa
por: Goodall, Ruth L., et al.
Publicado: (2017)

Identification of gaps for implementation science in the HIV prevention, care and treatment cascade; a qualitative study in 19 districts in Uganda
por: Bajunirwe, Francis, et al.
Publicado: (2016)

Differences in Clinical Manifestations of Acute and Early HIV-1 Infection between HIV-1 Subtypes in African Women
por: Lemonovich, Tracy L., et al.
Publicado: (2015)

Zidovudine-induced myopathy
por: Wiwanitkit, Viroj
Publicado: (2011)

Zidovudine Induced Hyperpigmentation
por: Premjith, Raveendran, et al.
Publicado: (2022)

Determinants of Clinician Knowledge on Aging and HIV/AIDS: A Survey of Practitioners and Policy Makers in Kampala District, Uganda
por: Obuku, Ekwaro A., et al.
Publicado: (2013)

Persistence of traditional and emergence of new structural drivers and factors for the HIV epidemic in rural Uganda; A qualitative study
por: Bajunirwe, Francis, et al.
Publicado: (2019)

Abacavir, zidovudine, or stavudine as paediatric tablets for African HIV-infected children (CHAPAS-3): an open-label, parallel-group, randomised controlled trial
por: Mulenga, Veronica, et al.
Publicado: (2016)

Clinical Differences between Younger and Older Adults with HIV/AIDS Starting Antiretroviral Therapy in Uganda and Zimbabwe: A Secondary Analysis of the DART Trial
por: Parikh, Sujal M., et al.
Publicado: (2013)

Reduced CCR5 expression among Uganda HIV controllers
por: Nyiro, Brian, et al.
Publicado: (2023)

Placental Transport of Zidovudine in the Rhesus Monkey
por: Ridgway III, Louis E., et al.
Publicado: (1993)

Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children
por: Fillekes, Quirine, et al.
Publicado: (2014)

Zidovudine-induced myopathy: A study in Indian patients
por: Sagar, Amitabh, et al.
Publicado: (2010)

Zidovudine-induced reversible pure red cell aplasia
por: Balakrishnan, Anuja, et al.
Publicado: (2010)

Effect of Zidovudine and its Interaction with Rocuronium on Neuromuscular Transmission
por: Barvaliya, M. J., et al.
Publicado: (2013)

A case of zidovudine induced pigmentation on palms and soles
por: Singh, Satyendra Kumar, et al.
Publicado: (2014)

Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites
por: Mu, Lingli, et al.
Publicado: (2016)

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus
por: Cong, Yu, et al.
Publicado: (2016)

Ozonation products of zidovudine and thymidine in oxidative water treatment
por: Funke, Jan, et al.
Publicado: (2021)

Teratogenic and Embryocidal Effects of Zidovudine (AZT) in Sprague-Dawley Rats
por: Christmas, James T., et al.
Publicado: (1995)

Ischemic maculopathy in zidovudine-induced anemia in an HIV-positive man
por: Yoganathan, Kathir, et al.
Publicado: (2008)

Development and characterization of gelatin based nanoparticles for targeted delivery of zidovudine
por: Jadhav, Namdeo R, et al.
Publicado: (2013)

HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters
por: Brenner, Bluma G., et al.
Publicado: (2017)

Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance
por: Mohammadzadeh, Nazanin, et al.
Publicado: (2019)

A Single CD4 Test with 250 Cells/Mm(3) Threshold Predicts Viral Suppression in HIV-Infected Adults Failing First-Line Therapy by Clinical Criteria
por: Gilks, Charles F., et al.
Publicado: (2013)

High Level of Viral Suppression and Low Switch Rate to Second-Line Antiretroviral Therapy among HIV-Infected Adult Patients Followed over Five Years: Retrospective Analysis of the DART Trial
por: Kityo, Cissy, et al.
Publicado: (2014)

Zidovudine/Lamivudine for HIV-1 Infection Contributes to Limb Fat Loss
por: van Vonderen, Marit G. A., et al.
Publicado: (2009)

Foetal Loss and Enhanced Fertility Observed in Mice Treated with Zidovudine or Nevirapine
por: Onwuamah, Chika K., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gkqfgklanmal8ts7ao2dfdmfh0