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GNB3 overexpression causes obesity and metabolic syndrome

The G-protein beta subunit 3 (GNB3) gene has been implicated in obesity risk; however, the molecular mechanism of GNB3-related disease is unknown. GNB3 duplication is responsible for a syndromic form of childhood obesity, and an activating DNA sequence variant (C825T) in GNB3 is also associated with...

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Detalles Bibliográficos
Autores principales: Ozdemir, Alev Cagla, Wynn, Grace M., Vester, Aimee, Weitzmann, M. Neale, Neigh, Gretchen N., Srinivasan, Shanthi, Rudd, M. Katharine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716578/
https://www.ncbi.nlm.nih.gov/pubmed/29206867
http://dx.doi.org/10.1371/journal.pone.0188763