Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis

Multiple myeloma (MM) is an incurable disease of malignant plasma B-cells that infiltrate the bone marrow (BM), resulting in bone destruction, anemia, renal impairment and infections. Physiologically, the BM microenvironment is hypoxic and this promotes MM progression and contributes to resistance t...

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Detalles Bibliográficos
Autores principales: Gastelum, Gilberto, Poteshkina, Aleksandra, Veena, Mysore, Artiga, Edgar, Weckstein, Geraldine, Frost, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716583/
https://www.ncbi.nlm.nih.gov/pubmed/29206844
http://dx.doi.org/10.1371/journal.pone.0188438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716583/
https://www.ncbi.nlm.nih.gov/pubmed/29206844
http://dx.doi.org/10.1371/journal.pone.0188438

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