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Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis
Multiple myeloma (MM) is an incurable disease of malignant plasma B-cells that infiltrate the bone marrow (BM), resulting in bone destruction, anemia, renal impairment and infections. Physiologically, the BM microenvironment is hypoxic and this promotes MM progression and contributes to resistance t...
Autores principales: | Gastelum, Gilberto, Poteshkina, Aleksandra, Veena, Mysore, Artiga, Edgar, Weckstein, Geraldine, Frost, Patrick |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716583/ https://www.ncbi.nlm.nih.gov/pubmed/29206844 http://dx.doi.org/10.1371/journal.pone.0188438 |
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