The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets

The hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filaments. Building upon our earlier 4.3 Å resolution cryo-EM structure (Monroe et al., 2017), we now report a 3.2 Å structure of Vps4 bound to an ESCRT-III peptide substrate. The new structure reveals th...

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Detalles Bibliográficos
Autores principales: Han, Han, Monroe, Nicole, Sundquist, Wesley I, Shen, Peter S, Hill, Christopher P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716660/
https://www.ncbi.nlm.nih.gov/pubmed/29165244
http://dx.doi.org/10.7554/eLife.31324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716660/
https://www.ncbi.nlm.nih.gov/pubmed/29165244
http://dx.doi.org/10.7554/eLife.31324

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