Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

GWAS have identified hundreds of height-associated loci. However, determining causal mechanisms is challenging, especially since height-relevant tissues (e.g. growth plates) are difficult to study. To uncover mechanisms by which height GWAS variants function, we performed epigenetic profiling of mur...

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Detalles Bibliográficos
Autores principales: Guo, Michael, Liu, Zun, Willen, Jessie, Shaw, Cameron P, Richard, Daniel, Jagoda, Evelyn, Doxey, Andrew C, Hirschhorn, Joel, Capellini, Terence D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716665/
https://www.ncbi.nlm.nih.gov/pubmed/29205154
http://dx.doi.org/10.7554/eLife.29329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716665/
https://www.ncbi.nlm.nih.gov/pubmed/29205154
http://dx.doi.org/10.7554/eLife.29329

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