Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling

Regulation of T cell function in the steady state is mediated by co-inhibitory receptors or immune checkpoints such as PD-1, CTLA-4, TIM-3 and LAG-3. Persistent antigen stimulation, during chronic viral infections and cancer, results in sustained expression of multiple co-inhibitory receptors and su...

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Detalles Bibliográficos
Autores principales: Okoye, Isobel, Namdar, Afshin, Xu, Lai, Crux, Nicole, Elahi, Shokrollah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716724/
https://www.ncbi.nlm.nih.gov/pubmed/29228684
http://dx.doi.org/10.18632/oncotarget.21003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716724/
https://www.ncbi.nlm.nih.gov/pubmed/29228684
http://dx.doi.org/10.18632/oncotarget.21003

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