MP0250, a VEGF and HGF neutralizing DARPin(®) molecule shows high anti-tumor efficacy in mouse xenograft and patient-derived tumor models

BACKGROUND: The VEGF/VEGFR and the HGF/cMET pathways are key mediators of the interplay of tumor cells and their microenvironment. However, inhibition of VEGF has been shown to produce only limited clinical benefit and inhibition of the activation of cMET by HGF has not translated into clinical bene...

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Detalles Bibliográficos
Autores principales: Fiedler, Ulrike, Ekawardhani, Savira, Cornelius, Andreas, Gilboy, Pat, Bakker, Talitha R., Dolado, Ignacio, Stumpp, Michael T., Dawson, Keith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716736/
https://www.ncbi.nlm.nih.gov/pubmed/29228696
http://dx.doi.org/10.18632/oncotarget.21738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716736/
https://www.ncbi.nlm.nih.gov/pubmed/29228696
http://dx.doi.org/10.18632/oncotarget.21738

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