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MP0250, a VEGF and HGF neutralizing DARPin(®) molecule shows high anti-tumor efficacy in mouse xenograft and patient-derived tumor models
BACKGROUND: The VEGF/VEGFR and the HGF/cMET pathways are key mediators of the interplay of tumor cells and their microenvironment. However, inhibition of VEGF has been shown to produce only limited clinical benefit and inhibition of the activation of cMET by HGF has not translated into clinical bene...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716736/ https://www.ncbi.nlm.nih.gov/pubmed/29228696 http://dx.doi.org/10.18632/oncotarget.21738 |