Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines

Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia. Here we show the antitumoral activity of ZINC69391 and 1A-116, two chemically-related Rac1 pharmacological inhibitors,...

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Detalles Bibliográficos
Autores principales: Cabrera, Maia, Echeverria, Emiliana, Lenicov, Federico Remes, Cardama, Georgina, Gonzalez, Nazareno, Davio, Carlos, Fernández, Natalia, Menna, Pablo Lorenzano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716746/
https://www.ncbi.nlm.nih.gov/pubmed/29228706
http://dx.doi.org/10.18632/oncotarget.21533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716746/
https://www.ncbi.nlm.nih.gov/pubmed/29228706
http://dx.doi.org/10.18632/oncotarget.21533

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