Increased single-strand annealing rather than non-homologous end-joining predicts hereditary ovarian carcinoma

Mutations in genes encoding DNA double-strand break (DSB) repair components, especially homologous recombination (HR) proteins, were found to predispose to breast and ovarian cancer. Beyond high penetrance risk gene mutations underlying monogenic defects, low risk gene mutations generate polygenic d...

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Detalles Bibliográficos
Autores principales: Deniz, Miriam, Romashova, Tatiana, Kostezka, Sarah, Faul, Anke, Gundelach, Theresa, Moreno-Villanueva, Maria, Janni, Wolfgang, Friedl, Thomas W.P., Wiesmüller, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716758/
https://www.ncbi.nlm.nih.gov/pubmed/29228718
http://dx.doi.org/10.18632/oncotarget.21720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716758/
https://www.ncbi.nlm.nih.gov/pubmed/29228718
http://dx.doi.org/10.18632/oncotarget.21720

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