Cargando…

Inhibition of A(2A) Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455

Several evidences indicate that the ubiquitous nucleoside adenosine, acting through A(1), A(2A), A(2B), and A(3) receptor (AR) subtypes, plays crucial roles in tumor development. Adenosine has contrasting effects on cell proliferation depending on the engagement of different receptor subtypes in var...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gessi, Stefania, Bencivenni, Serena, Battistello, Enrica, Vincenzi, Fabrizio, Colotta, Vittoria, Catarzi, Daniela, Varano, Flavia, Merighi, Stefania, Borea, Pier Andrea, Varani, Katia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716981/ https://www.ncbi.nlm.nih.gov/pubmed/29249971 http://dx.doi.org/10.3389/fphar.2017.00888

Ejemplares similares

A(1) Adenosine Receptor Partial Agonists and Allosteric Modulators: Advancing Toward the Clinic?
por: Vincenzi, Fabrizio, et al.
Publicado: (2020)

Adenosine Receptors in Neuropsychiatric Disorders: Fine Regulators of Neurotransmission and Potential Therapeutic Targets
por: Pasquini, Silvia, et al.
Publicado: (2022)

Novel selective antagonist radioligands for the pharmacological study of A(2B) adenosine receptors
por: Gessi, Stefania, et al.
Publicado: (2006)

Piperazine- and Piperidine-Containing Thiazolo[5,4-d]pyrimidine Derivatives as New Potent and Selective Adenosine A(2A) Receptor Inverse Agonists
por: Varano, Flavia, et al.
Publicado: (2020)

The Detrimental Action of Adenosine on Glutamate-Induced Cytotoxicity in PC12 Cells Can Be Shifted towards a Neuroprotective Role through A(1)AR Positive Allosteric Modulation
por: Vincenzi, Fabrizio, et al.
Publicado: (2020)

A(2A) Adenosine Receptor: A Possible Therapeutic Target for Alzheimer’s Disease by Regulating NLRP3 Inflammasome Activity?
por: Merighi, Stefania, et al.
Publicado: (2022)

Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists
por: Catarzi, Daniela, et al.
Publicado: (2019)

Pharmacology of Adenosine Receptors: Recent Advancements
por: Vincenzi, Fabrizio, et al.
Publicado: (2023)

An Open Question: Is the A(2A) Adenosine Receptor a Novel Target for Alzheimer’s Disease Treatment?
por: Merighi, Stefania, et al.
Publicado: (2021)

Special Issue “Adenosine Receptors as Attractive Targets in Human Diseases”
por: Catarzi, Daniela, et al.
Publicado: (2021)

A(2A) Adenosine Receptor as a Potential Biomarker and a Possible Therapeutic Target in Alzheimer’s Disease
por: Gessi, Stefania, et al.
Publicado: (2021)

The Anti-Tumor Effect of A(3) Adenosine Receptors Is Potentiated by Pulsed Electromagnetic Fields in Cultured Neural Cancer Cells
por: Vincenzi, Fabrizio, et al.
Publicado: (2012)

Strategies for Drug Delivery into the Brain: A Review on Adenosine Receptors Modulation for Central Nervous System Diseases Therapy
por: Fernandez, Mercedes, et al.
Publicado: (2023)

Pathophysiological Role and Medicinal Chemistry of A(2A) Adenosine Receptor Antagonists in Alzheimer’s Disease
por: Merighi, Stefania, et al.
Publicado: (2022)

Caffeine for Prevention of Alzheimer’s Disease: Is the A(2A) Adenosine Receptor Its Target?
por: Merighi, Stefania, et al.
Publicado: (2023)

Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields
por: Varani, Katia, et al.
Publicado: (2017)

Adenosine and lymphocyte regulation
por: Gessi, Stefania, et al.
Publicado: (2007)

Role and Function of A(2A) and A(3) Adenosine Receptors in Patients with Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis
por: Ravani, Annalisa, et al.
Publicado: (2017)

A(2A) Adenosine Receptors Are Differentially Modulated by Pharmacological Treatments in Rheumatoid Arthritis Patients and Their Stimulation Ameliorates Adjuvant-Induced Arthritis in Rats
por: Vincenzi, Fabrizio, et al.
Publicado: (2013)

Pulsed Electromagnetic Fields Increased the Anti-Inflammatory Effect of A(2A) and A(3) Adenosine Receptors in Human T/C-28a2 Chondrocytes and hFOB 1.19 Osteoblasts
por: Vincenzi, Fabrizio, et al.
Publicado: (2013)

Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
por: Merighi, Stefania, et al.
Publicado: (2006)

Adenosinergic System Involvement in Ischemic Stroke Patients’ Lymphocytes
por: Pasquini, Silvia, et al.
Publicado: (2020)

4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives
por: Catarzi, Daniela, et al.
Publicado: (2022)

The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A(1) and A(2A) receptor affinity and selectivity profiles
por: Squarcialupi, Lucia, et al.
Publicado: (2017)

Anxiolytic properties of A(1) adenosine receptor PAMs
por: Vincenzi, Fabrizio, et al.
Publicado: (2016)

Adenosine and Inflammation: Here, There and Everywhere
por: Pasquini, Silvia, et al.
Publicado: (2021)

Targeting Adenosine Receptors: A Potential Pharmacological Avenue for Acute and Chronic Pain
por: Vincenzi, Fabrizio, et al.
Publicado: (2020)

Pharmacological Characterization of P626, a Novel Dual Adenosine A(2A)/A(2B) Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus
por: Venturini, Martina, et al.
Publicado: (2023)

Update on the recent development of allosteric modulators for adenosine receptors and their therapeutic applications
por: Pasquini, Silvia, et al.
Publicado: (2022)

The Role of Adenosine Receptors in Psychostimulant Addiction
por: Ballesteros-Yáñez, Inmaculada, et al.
Publicado: (2018)

A(2A) adenosine receptor upregulation correlates with disease activity in patients with systemic lupus erythematosus
por: Bortoluzzi, Alessandra, et al.
Publicado: (2016)

Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A(1) and A(2A) Receptors, and Efficacy in Animal Models of Depression
por: Varano, Flavia, et al.
Publicado: (2021)

A(2A )and A(3 )adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release
por: Varani, Katia, et al.
Publicado: (2011)

Pulsed Electromagnetic Fields Stimulate HIF-1α-Independent VEGF Release in 1321N1 Human Astrocytes Protecting Neuron-like SH-SY5Y Cells from Oxygen-Glucose Deprivation
por: Vincenzi, Fabrizio, et al.
Publicado: (2020)

Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives
por: Piras, Sandra, et al.
Publicado: (2021)

“Dual Anta-Inhibitors” of the A(2A) Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies
por: Spinaci, Andrea, et al.
Publicado: (2023)

Microglia and Alzheimer’s Disease
por: Merighi, Stefania, et al.
Publicado: (2022)

A(2A) adenosine receptors are involved in the reparative response of tendon cells to pulsed electromagnetic fields
por: Colombini, Alessandra, et al.
Publicado: (2020)

Antioxidant and Antiinflammatory Effects of Epilobium parviflorum, Melilotus officinalis and Cardiospermum halicacabum Plant Extracts in Macrophage and Microglial Cells
por: Merighi, Stefania, et al.
Publicado: (2021)

Potentiating Cancer Immune Therapy via Nanomaterials and Purinergic Signaling
por: Ferrari, Davide, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_emcb35ls19rvo1drrhf1uil6ss