A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain

Intervertebral disc (IVD) degeneration is a major cause of low back pain. The transcription factor c-Fos/Activator Protein-1 (AP-1) controls the expression of inflammatory cytokines and matrix metalloproteinases (MMPs) that contribute to the pathogenesis IVD degeneration. We investigated the effects...

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Detalles Bibliográficos
Autores principales: Makino, Hiroto, Seki, Shoji, Yahara, Yasuhito, Shiozawa, Shunichi, Aikawa, Yukihiko, Motomura, Hiraku, Nogami, Makiko, Watanabe, Kenta, Sainoh, Takeshi, Ito, Hisakatsu, Tsumaki, Noriyuki, Kawaguchi, Yoshiharu, Yamazaki, Mitsuaki, Kimura, Tomoatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717052/
https://www.ncbi.nlm.nih.gov/pubmed/29208967
http://dx.doi.org/10.1038/s41598-017-17289-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717052/
https://www.ncbi.nlm.nih.gov/pubmed/29208967
http://dx.doi.org/10.1038/s41598-017-17289-y

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