Major depletion of SOX2(+) stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling

The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2(+) cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult Sox2(CreERT2/+);R26(iDTR/+) mice (after tamoxif...

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Detalles Bibliográficos
Autores principales: Roose, Heleen, Cox, Benoit, Boretto, Matteo, Gysemans, Conny, Vennekens, Annelies, Vankelecom, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717068/
https://www.ncbi.nlm.nih.gov/pubmed/29208952
http://dx.doi.org/10.1038/s41598-017-16796-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717068/
https://www.ncbi.nlm.nih.gov/pubmed/29208952
http://dx.doi.org/10.1038/s41598-017-16796-2

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