Na(+) entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

The sesquiterpene (−)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells. Here we identified selective cytotoxicity of EA in human synovial sarcoma cells (SW982...

Descripción completa

Detalles Bibliográficos
Autores principales: Muraki, Katsuhiko, Ohnishi, Kaori, Takezawa, Akiho, Suzuki, Hiroka, Hatano, Noriyuki, Muraki, Yukiko, Hamzah, Nurasyikin, Foster, Richard, Waldmann, Herbert, Nussbaumer, Peter, Christmann, Mathias, Bon, Robin S., Beech, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717101/
https://www.ncbi.nlm.nih.gov/pubmed/29209034
http://dx.doi.org/10.1038/s41598-017-17303-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717101/
https://www.ncbi.nlm.nih.gov/pubmed/29209034
http://dx.doi.org/10.1038/s41598-017-17303-3

Ejemplares similares