Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-Mad2), bound to Cdc20. C-Mad2–Cdc20 is incorporated into the mitotic checkpoint complex (MCC...

Descripción completa

Detalles Bibliográficos
Autores principales: Brulotte, Melissa L., Jeong, Byung-Cheon, Li, Faxiang, Li, Bing, Yu, Eric B., Wu, Qiong, Brautigam, Chad A., Yu, Hongtao, Luo, Xuelian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717197/
https://www.ncbi.nlm.nih.gov/pubmed/29208896
http://dx.doi.org/10.1038/s41467-017-02012-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717197/
https://www.ncbi.nlm.nih.gov/pubmed/29208896
http://dx.doi.org/10.1038/s41467-017-02012-2

Ejemplares similares