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Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-Mad2), bound to Cdc20. C-Mad2–Cdc20 is incorporated into the mitotic checkpoint complex (MCC...

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Detalles Bibliográficos
Autores principales:	Brulotte, Melissa L., Jeong, Byung-Cheon, Li, Faxiang, Li, Bing, Yu, Eric B., Wu, Qiong, Brautigam, Chad A., Yu, Hongtao, Luo, Xuelian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717197/ https://www.ncbi.nlm.nih.gov/pubmed/29208896 http://dx.doi.org/10.1038/s41467-017-02012-2

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