Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Trifluridine/tipiracil (TFTD, TAS-102) is an orally administrated anti-cancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC). Trifluridine (FTD) is an active cytotoxic component of TFTD and mediates the anticancer effect via its incorporation into DNA. However, it...

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Detalles Bibliográficos
Autores principales: Nakanishi, Ryota, Kitao, Hiroyuki, Kiniwa, Mamoru, Morodomi, Yosuke, Iimori, Makoto, Kurashige, Junji, Sugiyama, Masahiko, Nakashima, Yuichiro, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717244/
https://www.ncbi.nlm.nih.gov/pubmed/29208954
http://dx.doi.org/10.1038/s41598-017-17282-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717244/
https://www.ncbi.nlm.nih.gov/pubmed/29208954
http://dx.doi.org/10.1038/s41598-017-17282-5

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