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Broad modulus range nanomechanical mapping by magnetic-drive soft probes
Stiffness matching between the probe and deformed portion of the sample in piezo-drive peak force modulation atomic force microscopy (AFM) limits the modulus measurement range of single probes. Here we develop a magnetic drive peak force modulation AFM to broaden the dynamic range of the probe with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717272/ https://www.ncbi.nlm.nih.gov/pubmed/29208894 http://dx.doi.org/10.1038/s41467-017-02032-y |
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author | Meng, Xianghe Zhang, Hao Song, Jianmin Fan, Xinjian Sun, Lining Xie, Hui |
author_facet | Meng, Xianghe Zhang, Hao Song, Jianmin Fan, Xinjian Sun, Lining Xie, Hui |
author_sort | Meng, Xianghe |
collection | PubMed |
description | Stiffness matching between the probe and deformed portion of the sample in piezo-drive peak force modulation atomic force microscopy (AFM) limits the modulus measurement range of single probes. Here we develop a magnetic drive peak force modulation AFM to broaden the dynamic range of the probe with direct cantilever excitation. This approach not only successfully drives the softest commercial probe (6 pN nm(−1)) for mapping extremely soft samples in liquid but also provides an indentation force of hundreds of nanonewtons for stiff samples with a soft probe. Features of direct measurements of the indentation force and depth can unify the elastic modulus range up to four orders of magnitude, from 1 kPa to 10 MPa (in liquid) and 1 MPa to 20 GPa (in air or liquid) using a single probe. This approach can be particularly useful for analysing heterogeneous samples with large elastic modulus variations in multi-environments. |
format | Online Article Text |
id | pubmed-5717272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57172722017-12-08 Broad modulus range nanomechanical mapping by magnetic-drive soft probes Meng, Xianghe Zhang, Hao Song, Jianmin Fan, Xinjian Sun, Lining Xie, Hui Nat Commun Article Stiffness matching between the probe and deformed portion of the sample in piezo-drive peak force modulation atomic force microscopy (AFM) limits the modulus measurement range of single probes. Here we develop a magnetic drive peak force modulation AFM to broaden the dynamic range of the probe with direct cantilever excitation. This approach not only successfully drives the softest commercial probe (6 pN nm(−1)) for mapping extremely soft samples in liquid but also provides an indentation force of hundreds of nanonewtons for stiff samples with a soft probe. Features of direct measurements of the indentation force and depth can unify the elastic modulus range up to four orders of magnitude, from 1 kPa to 10 MPa (in liquid) and 1 MPa to 20 GPa (in air or liquid) using a single probe. This approach can be particularly useful for analysing heterogeneous samples with large elastic modulus variations in multi-environments. Nature Publishing Group UK 2017-12-05 /pmc/articles/PMC5717272/ /pubmed/29208894 http://dx.doi.org/10.1038/s41467-017-02032-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commonslicense, unless indicated otherwise in a credit line to the material. If material is not included in the article’sCreative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Meng, Xianghe Zhang, Hao Song, Jianmin Fan, Xinjian Sun, Lining Xie, Hui Broad modulus range nanomechanical mapping by magnetic-drive soft probes |
title | Broad modulus range nanomechanical mapping by magnetic-drive soft probes |
title_full | Broad modulus range nanomechanical mapping by magnetic-drive soft probes |
title_fullStr | Broad modulus range nanomechanical mapping by magnetic-drive soft probes |
title_full_unstemmed | Broad modulus range nanomechanical mapping by magnetic-drive soft probes |
title_short | Broad modulus range nanomechanical mapping by magnetic-drive soft probes |
title_sort | broad modulus range nanomechanical mapping by magnetic-drive soft probes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717272/ https://www.ncbi.nlm.nih.gov/pubmed/29208894 http://dx.doi.org/10.1038/s41467-017-02032-y |
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