Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking

Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 receptors. How CXCL8 monomer and dimer interactions...

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Detalles Bibliográficos
Autores principales: Joseph, Prem Raj B., Sawant, Kirti V., Rajarathnam, Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717344/
https://www.ncbi.nlm.nih.gov/pubmed/29118271
http://dx.doi.org/10.1098/rsob.170168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717344/
https://www.ncbi.nlm.nih.gov/pubmed/29118271
http://dx.doi.org/10.1098/rsob.170168

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