Cargando…

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

BACKGROUND: Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for use in cytoplasmic processes. The mitochondrial enzyme MTHFD2 has been reported...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shin, Minhye, Momb, Jessica, Appling, Dean R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718140/ https://www.ncbi.nlm.nih.gov/pubmed/29225823 http://dx.doi.org/10.1186/s40170-017-0173-0

Ejemplares similares

The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)
por: Zhao, Li Na, et al.
Publicado: (2022)

Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer
por: Eich, Marie-Lisa, et al.
Publicado: (2019)

Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)
por: Lee, Lung-Chun, et al.
Publicado: (2021)

Expression and Prognostic Value Identification of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Brain Low-Grade Glioma
por: Shi, Lu-feng, et al.
Publicado: (2021)

Assessment of Pseudomonas aeruginosa N (5),N (10)-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target
por: Eadsforth, Thomas C., et al.
Publicado: (2012)

Methylenetetrahydrofolate dehydrogenase (MTHFD) enzyme polymorphism as a maternal risk factor for trisomy 21: a clinical study
por: Neagos, D, et al.
Publicado: (2010)

The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target()
por: Eadsforth, Thomas C., et al.
Publicado: (2012)

High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance
por: He, Huan, et al.
Publicado: (2020)

Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?
por: Feng, Zichen, et al.
Publicado: (2022)

miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia
por: Gu, Yueli, et al.
Publicado: (2017)

Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach
por: Rana, Nisarg, et al.
Publicado: (2023)

Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis
por: He, Donglin, et al.
Publicado: (2018)

Exome sequencing identified novel variants in three Chinese patients with 5,10-methenyltetrahydrofolate synthetase deficiency
por: Xu, Xiaoyan, et al.
Publicado: (2023)

Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer
por: Chan, Chun-Hao, et al.
Publicado: (2020)

Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications
por: Ju, Huai-Qiang, et al.
Publicado: (2018)

A redox probe screens MTHFD1 as a determinant of gemcitabine chemoresistance in cholangiocarcinoma
por: Pan, Ruogu, et al.
Publicado: (2021)

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform
por: Zhang, Linyue, et al.
Publicado: (2022)

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2
por: Asai, Ayumu, et al.
Publicado: (2018)

Crystal structure of Thermus thermophilus methylenetetrahydrofolate dehydrogenase and determinants of thermostability
por: Maiello, Fernando, et al.
Publicado: (2020)

ATF4/MYC Regulates MTHFD2 to Promote NSCLC Progression by Mediating Redox Homeostasis
por: Gao, Yixing, et al.
Publicado: (2022)

Minimal Pathway for the Regeneration of Redox Cofactors
por: Partipilo, Michele, et al.
Publicado: (2021)

Association of Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms with Cancer: A Meta-Analysis
por: Zhang, Hongtuan, et al.
Publicado: (2013)

A case of 5,10-methenyltetrahydrofolate synthetase deficiency due to biallelic null mutations with novel findings of elevated neopterin and macrocytic anemia
por: Romero, Jacqueline A., et al.
Publicado: (2019)

MTHFD1L-Mediated Redox Homeostasis Promotes Tumor Progression in Tongue Squamous Cell Carcinoma
por: Li, Hao, et al.
Publicado: (2019)

Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L)
por: Leow, Melvin Khee-Shing, et al.
Publicado: (2022)

Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease
por: Liu, Hanjun, et al.
Publicado: (2023)

MTHFD2- a new twist?
por: Tedeschi, Philip M., et al.
Publicado: (2016)

Shifting Redox Reaction Equilibria on Demand Using an Orthogonal Redox Cofactor
por: Aspacio, Derek, et al.
Publicado: (2023)

Menaquinone-7 Is Specific Cofactor in Tetraheme Quinol Dehydrogenase CymA
por: McMillan, Duncan G. G., et al.
Publicado: (2012)

The Protein Partners of GTP Cyclohydrolase I in Rat Organs
por: Du, Jianhai, et al.
Publicado: (2012)

Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolò E., et al.
Publicado: (2014)

Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell
por: Wan, Xingyou, et al.
Publicado: (2020)

Engineering of Escherichia coli Glyceraldehyde-3-Phosphate Dehydrogenase with Dual NAD(+)/NADP(+) Cofactor Specificity for Improving Amino Acid Production
por: Slivinskaya, Ekaterina A., et al.
Publicado: (2022)

Molecular structure of a 5,10‐methylenetetrahydrofolate dehydrogenase from the silkworm Bombyx mori
por: Haque, Mohammad R., et al.
Publicado: (2019)

Applying Non-canonical Redox Cofactors in Fermentation Processes
por: Weusthuis, Ruud A., et al.
Publicado: (2020)

Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors
por: Colston, Kyle J., et al.
Publicado: (2022)

Targeting MTHFD2 in acute myeloid leukemia
por: Pikman, Yana, et al.
Publicado: (2016)

MTHFD1 controls DNA methylation in Arabidopsis
por: Groth, Martin, et al.
Publicado: (2016)

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
por: Kümpornsin, Krittikorn, et al.
Publicado: (2014)

Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolo E., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pd2q6n80v5rkeqvcepceamkvq5