Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and become major contributors to fibrosis, by increasing...

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Detalles Bibliográficos
Autores principales: Saison-Ridinger, Maya, DelGiorno, Kathleen E., Zhang, Tejia, Kraus, Annabelle, French, Randall, Jaquish, Dawn, Tsui, Crystal, Erikson, Galina, Spike, Benjamin T., Shokhirev, Maxim N., Liddle, Christopher, Yu, Ruth T., Downes, Michael, Evans, Ronald M., Saghatelian, Alan, Lowy, Andrew M., Wahl, Geoffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718507/
https://www.ncbi.nlm.nih.gov/pubmed/29211796
http://dx.doi.org/10.1371/journal.pone.0189051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718507/
https://www.ncbi.nlm.nih.gov/pubmed/29211796
http://dx.doi.org/10.1371/journal.pone.0189051

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