Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice

We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes. This method identified monoclonal antibody epitopes and predicted additional epitopes reco...

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Detalles Bibliográficos
Autores principales: Mitchell, Daniel A. J., Dupuy, Lesley C., Sanchez-Lockhart, Mariano, Palacios, Gustavo, Back, Jaap W., Shimanovskaya, Katya, Chaudhury, Sidhartha, Ripoll, Daniel R., Wallqvist, Anders, Schmaljohn, Connie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718802/
https://www.ncbi.nlm.nih.gov/pubmed/28699812
http://dx.doi.org/10.1080/21645515.2017.1347740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718802/
https://www.ncbi.nlm.nih.gov/pubmed/28699812
http://dx.doi.org/10.1080/21645515.2017.1347740

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