Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice

Amyloid-β (Aβ) and tau pathologies are intertwined in Alzheimer’s disease, and various immunotherapies targeting these hallmarks are in clinical trials. To determine if tau pathology influences Aβ burden and to assess prophylactic benefits, 3xTg and wild-type mice received tau immunization from 2–6...

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Detalles Bibliográficos
Autores principales: Rajamohamedsait, Hameetha, Rasool, Suhail, Rajamohamedsait, Wajitha, Lin, Yan, Sigurdsson, Einar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719023/
https://www.ncbi.nlm.nih.gov/pubmed/29213096
http://dx.doi.org/10.1038/s41598-017-17313-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719023/
https://www.ncbi.nlm.nih.gov/pubmed/29213096
http://dx.doi.org/10.1038/s41598-017-17313-1

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