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Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice
Amyloid-β (Aβ) and tau pathologies are intertwined in Alzheimer’s disease, and various immunotherapies targeting these hallmarks are in clinical trials. To determine if tau pathology influences Aβ burden and to assess prophylactic benefits, 3xTg and wild-type mice received tau immunization from 2–6...
Autores principales: | Rajamohamedsait, Hameetha, Rasool, Suhail, Rajamohamedsait, Wajitha, Lin, Yan, Sigurdsson, Einar M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719023/ https://www.ncbi.nlm.nih.gov/pubmed/29213096 http://dx.doi.org/10.1038/s41598-017-17313-1 |
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