Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

Antibodies have enormous therapeutic and biotechnology potential. G protein-coupled receptors (GPCRs), the main targets in drug development, are of major interest in antibody development programs. Metabotropic glutamate receptors are dimeric GPCRs that can control synaptic activity in a multitude of...

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Detalles Bibliográficos
Autores principales: Scholler, Pauline, Nevoltris, Damien, de Bundel, Dimitri, Bossi, Simon, Moreno-Delgado, David, Rovira, Xavier, Møller, Thor C., El Moustaine, Driss, Mathieu, Michaël, Blanc, Emilie, McLean, Heather, Dupuis, Elodie, Mathis, Gérard, Trinquet, Eric, Daniel, Hervé, Valjent, Emmanuel, Baty, Daniel, Chames, Patrick, Rondard, Philippe, Pin, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719040/
https://www.ncbi.nlm.nih.gov/pubmed/29213077
http://dx.doi.org/10.1038/s41467-017-01489-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719040/
https://www.ncbi.nlm.nih.gov/pubmed/29213077
http://dx.doi.org/10.1038/s41467-017-01489-1

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