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Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype
Foxp3, a key transcription factor that drives lineage differentiation of regulatory T cells (Tregs), was thought to imprint a unique and irreversible genetic signature within Tregs. Recent evidence, however, suggests that loss or attenuation of Foxp3 expression can cause Tregs to de-differentiate in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719048/ https://www.ncbi.nlm.nih.gov/pubmed/29213081 http://dx.doi.org/10.1038/s41598-017-17078-7 |