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The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway

In vertebrates, PIAS genes encode versatile cellular regulators, with functions extremely complex and redundant. Here we try to understand their functions from an evolutionary perspective. we evaluate the sequences, expression and molecular functions of amphioxus PIAS genes and compare them with the...

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Detalles Bibliográficos
Autores principales: Wang, Ruihua, Huang, Shengfeng, Fu, Xianan, Huang, Guangrui, Yan, Xinyu, Yue, Zirui, Chen, Shangwu, Li, Yingqiu, Xu, Anlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719053/
https://www.ncbi.nlm.nih.gov/pubmed/29213053
http://dx.doi.org/10.1038/s41598-017-16624-7